Sugi Predict

Sugi Predict / Compounds / SCHEMBL6401983

SCHEMBL6401983

SCHEMBL6401983

CC(c1cccc(O)c1)C(O)(O)c1c(O)cccc1SP(=O)(O)O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADRB1 P08588 2/20 0.35
▸ ADRA1A P35348 2/20 0.35
▸ MIF P14174 1/20 0.35
▸ HTR2A P28223 1/20 0.35
▸ HTR2B P41595 1/20 0.35
▸ KDM4E B2RXH2 4/20 0.33
▸ HIF1A Q16665 3/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ HDAC4 P56524 2/20 0.33
▸ HDAC2 Q92769 2/20 0.33
▸ HDAC8 Q9BY41 2/20 0.33
▸ MDM4 O15151 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ TYR P14679 1/20 0.33
▸ HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6404456 0.89 ADRB1 (0.37) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6401894 0.89 ESR1 (0.32) ESR1ESR2PTPN5
SCHEMBL6401058 0.85 HDAC4 (0.33) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6395701 0.82 HDAC4 (0.36) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6402302 0.81 ADRB1 (0.35) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6399924 0.81 ADRB1 (0.35) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6401986 0.81 ADRB1 (0.37) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6398644 0.78 INPPL1 (0.38) ADRB1ADRA1AMIFHTR2AHTR2B
SCHEMBL6396077 0.77 CYP2C9 (0.33) ADRA1AMAPTLMNACYP3A4ALOX15
SCHEMBL6397895 0.76 ESR1 (0.32) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050187195-A1 Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans PEERCE BRIAN E (US) 2005-08-25 — — US disclosed
US-6787528-B2 THERAPY FOR KIDNEY DISEASES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2004-09-07 — — US disclosed
US-20030162753-A1 Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2003-08-28 — — US disclosed
US-20020133036-A1 Inhibitors of intestinal apical membrane Na/phosphate co-transportation PEERCE BRIAN E (US) 2002-09-19 — — US disclosed
US-6355823-B1 MEMBRANE SUBSTRATE PHOSPHATED FOR DRUGS FOR GASTROINTESTINAL DISORDERS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2002-03-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050187195-A1 Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans SLC34A3, SLC34A1, SLC34A2 ADRB1 1543/4885ADRA1A 2552/4885MIF 1786/4885
US-20020133036-A1 Inhibitors of intestinal apical membrane Na/phosphate co-transportation SLC10A2, SLC34A3, SLC34A1 ADRB1 1645/4885ADRA1A 2707/4885MIF 2109/4885
US-20030162753-A1 Inhibition of intestinal apical membrane Na/phosphate co-transportation in humans SLC34A3, SLC34A1, SLC34A2 ADRB1 1543/4885ADRA1A 2552/4885MIF 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.