Sugi Predict

Sugi Predict / Compounds / SCHEMBL6402349

SCHEMBL6402349

SCHEMBL6402349

CC(C)(C)OC(=O)N1CCC(c2ccc(N3C[C@H](CO)OC3=O)cc2F)CC1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CALML3 P27482 7/20 0.48
▸ MAOA P21397 6/20 0.48
▸ GPR119 Q8TDV5 2/20 0.47
▸ MAOB P27338 8/20 0.47
▸ USP30 Q70CQ3 1/20 0.46
▸ LMNA P02545 1/20 0.44
▸ PTGS1 P23219 1/20 0.44
▸ SDHA P31040 1/20 0.44
▸ F10 P00742 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6402350 1.00 CALML3 (0.48) CALML3MAOAGPR119MAOBUSP30
SCHEMBL7708541 0.93 MAOA (0.46) CALML3MAOAGPR119MAOBUSP30
SCHEMBL7708542 0.93 MAOA (0.46) CALML3MAOAGPR119MAOBUSP30
SCHEMBL6395268 0.92 MAOA (0.49) CALML3MAOAGPR119MAOBUSP30
SCHEMBL6395262 0.92 MAOA (0.49) CALML3MAOAGPR119MAOBUSP30
SCHEMBL7971517 0.89 MAOA (0.59) CALML3MAOAGPR119MAOBLMNA
SCHEMBL7971520 0.89 MAOA (0.59) CALML3MAOAGPR119MAOBLMNA
SCHEMBL6402366 0.88 GPR119 (0.51) CALML3MAOAGPR119MAOBUSP30
SCHEMBL6402364 0.88 GPR119 (0.51) CALML3MAOAGPR119MAOBUSP30
SCHEMBL6397223 0.88 CALML3 (0.44) CALML3MAOAMAOBUSP30LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050054683-A1 Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings HUTCHINSON DOUGLAS K (US) 2005-03-10 — — US disclosed
US-6358942-B1 MICROBIOCIDES AND BACTERICIDES FOR TREATING GRAMPOSITIVE, BACTEROIDES, CLOSTRIDIUM, MYCOBACTERIUM, STAPHYLOCOCCUS AND STREPTOCOCCUS INFECTIONS PHARMACIA & UPJOHN COMPANY 2002-03-19 — — US disclosed
US-6313307-B1 DEBLOCKING, DEPROTECTING; CATALYTIC HYDROGENATION, ALKYLATION; PREPARING MICROBIOCIDES AGAINST STAPHYLOCOCCUS, STREPTOCOCCUS, MYCOBACTERIUM, AND CLOSTRIDIUM PHARMACIA & UPJOHN COMPANY 2001-11-06 — — US disclosed
EP-0856002-B1 PHENYLOXAZOLIDINONES HAVING A C-C BOND TO 4-8 MEMBERED HETEROCYCLIC RINGS UPJOHN CO (US) 2001-10-24 — — EP disclosed
US-6051716-A ANTIMICROBIAL AGENTS PHARMACIA & UPJOHN, INC. (US) 2000-04-18 — — US disclosed
US-6043266-A MICROBIOCIDES TREATING GRAM-POSITIVE BACTERIA INFECTIONS AND PERSONS WITH AIDS PHARMACIA & UPJOHN COMPANY (US) 2000-03-28 — — US disclosed
US-5968962-A ANTIMICROBIAL AGENTS; EFFECTIVE AGAINST GRAMPOSITIVE BACTERIA PHARMACIA & UPJOHN COMPANY (US) 1999-10-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050054683-A1 Phenyloxazolidinones having a C-C bond to 4-8 membered heterocyclic rings CBR1, NCOR1, RCOR1 CALML3 3240/4885MAOA 2948/4885GPR119 1593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.