Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.74 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.74 |
| ▸ | DRD2 | P14416 | 4/20 | 0.71 |
| ▸ | HTR2A | P28223 | 4/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.71 |
| ▸ | HRH1 | P35367 | 4/20 | 0.71 |
| ▸ | DRD3 | P35462 | 4/20 | 0.71 |
| ▸ | HTR2B | P41595 | 4/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.71 |
| ▸ | HTR6 | P50406 | 3/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.71 |
| ▸ | HTR1A | P08908 | 3/20 | 0.71 |
| ▸ | DRD4 | P21917 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16256973 | 0.92 | OPRM1 (0.67) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL11669922 | 0.92 | OPRM1 (0.71) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL5296387 | 0.92 | OPRM1 (0.67) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL11932466 | 0.89 | OPRM1 (0.72) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL904846 | 0.88 | OPRM1 (0.62) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL10735272 | 0.87 | DRD2 (0.86) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL11506507 | 0.87 | DRD2 (0.57) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL9912156 | 0.86 | OPRL1 (0.74) | OPRM1OPRK1OPRL1OPRD1DRD4 | |
| SCHEMBL904933 | 0.86 | OPRM1 (0.60) | OPRM1OPRK1OPRL1OPRD1DRD2 | |
| SCHEMBL13964192 | 0.86 | OPRL1 (0.74) | OPRM1OPRK1OPRL1OPRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | ACADIA PHARMACEUTICALS INC. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130961-A1 | Muscarinic M1 receptor agonists for pain management | CHRM1, CHRM3, CHRM2 | OPRM1 6/4885OPRK1 11/4885OPRL1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.