Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.47 |
| ▸ | EIF4H | Q15056 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6401017 | 0.78 | POLB (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6401015 | 0.78 | POLB (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4682241 | 0.78 | MAPT (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6400986 | 0.78 | P2RX7 (0.37) | MEN1KMT2AP2RX7PABPC1L3MBTL1 | |
| SCHEMBL4682237 | 0.78 | MAPT (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6400987 | 0.78 | P2RX7 (0.37) | MEN1KMT2AP2RX7PABPC1L3MBTL1 | |
| SCHEMBL14267836 | 0.78 | P2RX7 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14257461 | 0.78 | P2RX7 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11233622 | 0.76 | MEN1 (0.62) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29653970 | 0.76 | MEN1 (0.62) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | ABBOTT LABORATORIES | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | P2RX3, P2RX7, P2RX1 | MEN1 4689/4885KMT2A 4090/4885ALDH1A1 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.