Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402618 | 0.85 | TLR8 (0.37) | ALDH1A1RAB9AMAPK1NPC1TLR8 | |
| SCHEMBL8687585 | 0.84 | ALDH1A1 (0.40) | ALDH1A1RAB9AMAPK1NPC1PIK3CD | |
| SCHEMBL6403120 | 0.84 | ALDH1A1 (0.40) | ALDH1A1RAB9AMAPK1NPC1PIK3CD | |
| SCHEMBL6403131 | 0.82 | TLR8 (0.40) | TLR8TSHR | |
| SCHEMBL6401579 | 0.82 | TLR8 (0.40) | TLR8TSHR | |
| SCHEMBL6397725 | 0.82 | TLR8 (0.40) | TLR8TSHR | |
| SCHEMBL7634469 | 0.80 | NPC1 (0.37) | ALDH1A1RAB9AMAPK1NPC1PIK3CD | |
| SCHEMBL6403072 | 0.79 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1SMN1; SMN2CYP3A4 | |
| SCHEMBL7635304 | 0.79 | NPC1 (0.36) | ALDH1A1RAB9AMAPK1NPC1PIK3CD | |
| SCHEMBL7636300 | 0.77 | NPC1 (0.35) | ALDH1A1RAB9AMAPK1NPC1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356271-B1 | 2,4-Diamino-pyrimidine-3-oxide derivatives and their use in the treatment and the prevention of hair drop | OREAL (FR) | 1995-04-05 | — | — | EP | claimed |
| US-4973474-A | 2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and prevention of hair loss | L'OREAL (FR) | 1990-11-27 | — | — | US | claimed |
| US-20050049232-A1 | Composition | LINDAU PAR (SE) | 2005-03-03 | — | — | US | disclosed |
| EP-1463483-A1 | NEW COMPOSITION | Ponsus Pharma AB (SE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003055454-A1 | NEW COMPOSITION | PONSUS PHARMA AB (SE) | 2003-07-10 | — | — | WO | disclosed |
| US-4973474-A | 2,4-diaminopyrimidine 3-oxide derivatives and their use for the treatment and prevention of hair loss | L'OREAL (FR) | 1990-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049232-A1 | Composition | CUTA, LIPG, LIPA | ALDH1A1 1751/4885RAB9A 4327/4885MAPK1 2907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.