Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014699 | 0.81 | F10 (0.48) | HTTMAPTMEN1KMT2AMITF | |
| SCHEMBL6341348 | 0.80 | POLB (0.74) | L3MBTL1POLBHTR7HTR6 | |
| SCHEMBL6338842 | 0.78 | POLB (0.80) | L3MBTL1POLBHTR7HTR6 | |
| SCHEMBL6340299 | 0.76 | ALDH1A1 (0.56) | HTTALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL4629666 | 0.76 | ALDH1A1 (0.57) | HTTALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL14093532 | 0.75 | HTR2C (0.48) | HTTMAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL6340577 | 0.75 | HTR7 (0.70) | ALDH1A1POLBHTR7HTR6 | |
| SCHEMBL4629544 | 0.75 | ALDH1A1 (0.56) | HTTALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL4629901 | 0.74 | ALDH1A1 (0.58) | HTTALDH1A1LMNAL3MBTL1RAB9A | |
| SCHEMBL6337236 | 0.74 | HTR7 (0.68) | ALDH1A1POLBHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |