Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340577 | 0.99 | HTR7 (0.70) | HTR7POLBALDH1A1HTR1AADRA2A | |
| SCHEMBL6338842 | 0.91 | POLB (0.80) | HTR7POLBHTR1AADRA2ADRD2 | |
| SCHEMBL6341348 | 0.90 | POLB (0.74) | HTR7POLBHTR1AADRA2ADRD2 | |
| SCHEMBL9895010 | 0.87 | HTR7 (0.65) | HTR7POLBALDH1A1HTR1AADRA2A | |
| SCHEMBL7426154 | 0.86 | HTR7 (0.61) | HTR7POLBALDH1A1HTR1AADRA2A | |
| SCHEMBL24069077 | 0.85 | HTR7 (0.87) | HTR7POLBALDH1A1HTR1AADRA2A | |
| SCHEMBL25758471 | 0.83 | HTR7 (0.60) | HTR7POLBALDH1A1HTR1AADRA2A | |
| SCHEMBL4196782 | 0.83 | SIGMAR1 (0.73) | HTR7SIGMAR1PARP1 | |
| SCHEMBL4617661 | 0.81 | SFRP1 (0.61) | HTR7ALDH1A1SIGMAR1PARP1 | |
| SCHEMBL6568486 | 0.81 | SIGMAR1 (0.72) | HTR7ALDH1A1SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |