Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 3/20 | 0.40 |
| ▸ | MMP16 | P51512 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640147 | 0.88 | PPARG (0.45) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL15891016 | 0.87 | MMP2 (0.48) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL639665 | 0.85 | MMP2 (0.44) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL638525 | 0.74 | PGR (0.38) | — | |
| SCHEMBL639915 | 0.72 | PPARG (0.49) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL640430 | 0.72 | HCRTR1 (0.38) | PTGDR2PTGDRHCRTR1HCRTR2PPARG | |
| SCHEMBL640318 | 0.72 | MMP2 (0.52) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL639891 | 0.72 | PTGDR2 (0.39) | MMP2PTGDR2PTGDRMMP9HCRTR1 | |
| SCHEMBL639664 | 0.70 | HCRTR1 (0.39) | MMP2PTGDR2PTGDRMMP9MMP3 | |
| SCHEMBL640722 | 0.69 | HCRTR1 (0.35) | PTGDR2PTGDRHCRTR1HCRTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791148-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |