Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15891015 | 0.87 | CXCL8 (0.42) | PPARGPPARDPPARAALDH1A1HTR6 | |
| SCHEMBL640146 | 0.86 | PPARG (0.45) | PPARGPPARDPPARAALDH1A1HTR6 | |
| SCHEMBL639664 | 0.78 | HCRTR1 (0.39) | HCRTR1HCRTR2ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL639665 | 0.74 | MMP2 (0.44) | HCRTR1HCRTR2PPARGPPARDPPARA | |
| SCHEMBL639891 | 0.73 | PTGDR2 (0.39) | HCRTR1HCRTR2PPARGPPARDPPARA | |
| SCHEMBL640431 | 0.72 | MMP2 (0.40) | HCRTR1HCRTR2PPARGPPARDPPARA | |
| SCHEMBL640722 | 0.71 | HCRTR1 (0.35) | HCRTR1HCRTR2PPARGPPARDPPARA | |
| SCHEMBL641893 | 0.70 | HCRTR1 (0.40) | HCRTR1HCRTR2ALDH1A1CCR6 | |
| SCHEMBL639699 | 0.69 | HCRTR1 (0.39) | HCRTR1HCRTR2ALDH1A1FNTAFNTB | |
| SCHEMBL639854 | 0.69 | HCRTR1 (0.39) | HCRTR1HCRTR2ALDH1A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791148-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-07-29 | — | — | US | disclosed |
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |