Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6401367 | 0.86 | PDE3B (0.55) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5569294 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2GAANPC1RAB9AHTT | |
| SCHEMBL16157009 | 0.78 | PDE3B (0.76) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL5681167 | 0.74 | PDE3B (0.56) | PDE3BPDE3AMAPTPDE4APDE4B | |
| SCHEMBL11289838 | 0.73 | PDE3B (0.55) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL16157204 | 0.72 | PDE3B (0.61) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL31117000 | 0.72 | PDE3B (0.61) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1143156 | 0.71 | ACHE (0.72) | SMN1; SMN2GAANPC1RAB9AHTT | |
| SCHEMBL16157001 | 0.71 | PDE3B (0.77) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10741604 | 0.71 | PDE3B (0.77) | SMN1; SMN2PDE3BPDE3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | TYMP, TPMT, PDXK | SMN1; SMN2 4713/4885GAA 1598/4885PDE3B 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.