Diethoxyflourescein

Diethoxyflourescein

SCHEMBL6404797

CCOc1ccc2c(c1)Oc1cc(OCC)ccc1C21OC(=O)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 1.00
MAPT P10636 5/20 0.68
LMNA P02545 5/20 0.68
MEN1 O00255 4/20 0.68
KMT2A Q03164 4/20 0.68
HTT P42858 2/20 0.68
USP2 O75604 2/20 0.68
ALDH1A1 P00352 1/20 0.68
FTO Q9C0B1 4/20 0.60
TDP1 Q9NUW8 3/20 0.60
CYP2C19 P33261 2/20 0.60
RECQL P46063 2/20 0.60
BLM P54132 2/20 0.60
PRMT1 Q99873 2/20 0.60
ACE2 Q9BYF1 2/20 0.60
HPGD P15428 1/20 0.60
SMAD3 P84022 1/20 0.60
GSTP1 P09211 1/20 0.52
NPSR1 Q6W5P4 3/20 0.47
POLB P06746 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3164943 0.93 CYP3A4 (0.87) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL22900773 0.93 CYP3A4 (0.87) CYP3A4MAPTLMNAMEN1KMT2A
Naphthalene SCHEMBL3166641 0.90 CYP3A4 (0.81) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL20777532 0.90 CYP3A4 (0.81) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL14750866 0.88 CYP3A4 (0.78) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL25759008 0.87 CYP3A4 (0.77) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL17227486 0.87 CYP3A4 (0.77) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL10264703 0.86 CYP3A4 (0.75) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL29386324 0.85 CYP3A4 (0.74) CYP3A4MAPTLMNAMEN1KMT2A
SCHEMBL1930643 0.85 CYP3A4 (0.74) CYP3A4MAPTLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1537853-A1 Use of a composition comprising a compound comprising a lacton ring and/or a corresponding coloring agent with an open ring for dyeing keratinuous fibers L'OREAL (FR) 2005-06-08 EP claimed
US-9745487-B2 Yellow thermochromic dyes, inks composition and level indicators CHROMATIC TECHNOLOGIES, INC. (US) 2017-08-29 US disclosed
US-9745487-B2 Yellow thermochromic dyes, inks composition and level indicators CHROMATIC TECHNOLOGIES, INC. (US) 2017-08-29 US disclosed
EP-3017010-B1 YELLOW THERMOCHROMIC DYES, INKS COMPOSITION AND LEVEL INDICATORS CHROMATIC TECH INC (US) 2017-05-17 EP disclosed
US-20160333210-A1 Yellow Thermochromic Dyes, Inks Composition And Level Indicators CHROMATIC TECHNOLOGIES, INC. (US) 2016-11-17 US disclosed
US-20160333210-A1 Yellow Thermochromic Dyes, Inks Composition And Level Indicators CHROMATIC TECHNOLOGIES, INC. (US) 2016-11-17 US disclosed
US-9399716-B2 Yellow thermochromic dyes, inks composition and level indicators CHROMATIC TECHNOLOGIES INC. (US) 2016-07-26 US disclosed
US-9399716-B2 Yellow thermochromic dyes, inks composition and level indicators CHROMATIC TECHNOLOGIES INC. (US) 2016-07-26 US disclosed
WO-2015003046-A1 YELLOW THERMOCHROMIC DYES, INKS COMPOSITION AND LEVEL INDICATORS CHROMATIC TECHNOLOGIES INC. (US) 2015-01-08 WO disclosed
EP-1238097-B9 DIETHOXYFLUORESCEIN AS INDICATOR FOR CYTOCHROME P450 SMITHKLINE BEECHAM PLC (GB) 2007-05-30 EP disclosed
EP-1537853-A1 Use of a composition comprising a compound comprising a lacton ring and/or a corresponding coloring agent with an open ring for dyeing keratinuous fibers L'OREAL (FR) 2005-06-08 EP disclosed
EP-1180244-A2 HIGH TROUGHPUT ASSAY SYSTEMS AND METHODS Caliper Technologies Corporation (US) 2002-02-20 EP disclosed
WO-2000070353-A2 HIGH THROUGHPUT ASSAY SYSTEMS AND METHODS CALIPER TECHNOLOGIES CORP. (US) 2000-11-23 WO disclosed