Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410915 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TP53HTTGPR139HDAC4 | |
| SCHEMBL7912225 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TP53HTTGPR139HDAC4 | |
| SCHEMBL6413085 | 0.85 | CYP2D6 (0.50) | ALDH1A1HDAC4HSD11B1MEN1KMT2A | |
| SCHEMBL6405636 | 0.85 | CYP2D6 (0.50) | ALDH1A1HDAC4HSD11B1MEN1KMT2A | |
| SCHEMBL6406223 | 0.85 | CYP2D6 (0.50) | ALDH1A1HDAC4HSD11B1MEN1KMT2A | |
| SCHEMBL6413090 | 0.85 | CYP2D6 (0.50) | ALDH1A1HDAC4HSD11B1MEN1KMT2A | |
| SCHEMBL14491529 | 0.83 | HDAC4 (0.60) | ALDH1A1TP53HTTHDAC4LMNA | |
| SCHEMBL5358777 | 0.83 | HDAC4 (0.60) | ALDH1A1TP53HTTHDAC4LMNA | |
| SCHEMBL14491528 | 0.83 | HDAC4 (0.60) | ALDH1A1TP53HTTHDAC4LMNA | |
| SCHEMBL4971403 | 0.83 | HDAC4 (0.46) | ALDH1A1HTTHDAC4LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | claimed |
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288338-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | ALDH1A1 345/4885TP53 4768/4885HTT 3466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.