Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | B3GNT2 | Q9NY97 | 3/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640633 | 0.80 | B3GNT2 (0.54) | B3GNT2DAOMDM2 | |
| SCHEMBL14827575 | 0.79 | POLB (0.59) | POLBB3GNT2DAOALDH1A1HPGD | |
| SCHEMBL27801894 | 0.79 | POLB (0.59) | POLBB3GNT2DAOALDH1A1MEN1 | |
| SCHEMBL27143489 | 0.78 | POLB (0.58) | POLBB3GNT2DAOALDH1A1HPGD | |
| SCHEMBL14664128 | 0.77 | POLB (0.54) | POLBB3GNT2DAOALDH1A1HPGD | |
| SCHEMBL639518 | 0.77 | POLB (0.57) | POLBDAOALDH1A1MEN1CYP1A2 | |
| SCHEMBL10833903 | 0.76 | POLB (0.70) | POLBB3GNT2DAOALDH1A1HPGD | |
| SCHEMBL904825 | 0.76 | POLB (0.74) | POLBB3GNT2DAOALDH1A1HPGD | |
| SCHEMBL261055 | 0.75 | FBP1 (0.41) | B3GNT2ALDH1A1 | |
| SCHEMBL261054 | 0.75 | FBP1 (0.41) | B3GNT2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119676-B2 | Substituted benzimidazolone derivatives, medicaments comprising them and their use | Abbott GmbH & Co. HG (DE) | 2012-02-21 | — | — | US | disclosed |
| US-8003792-B2 | CGRP (Calcitonin Gene-Related Peptide); migraine and cluster headaches; 2-(5-Bromo-1'1'-dioxido-2-oxo-2',3',5',6'-tetrahydrospiro[indole-3,4'-thiopyran]-1 (2H)-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)acetamide for example; use with other drugs | MERCK SHARP & DOHME CORP. (US) | 2011-08-23 | — | — | US | disclosed |