SCHEMBL6407178

SCHEMBL6407178

COc1ccnc2c1C(=O)c1nccc3ccnc-2c13

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.50
KMT2A Q03164 4/20 0.50
MAPK1 P28482 3/20 0.50
HTT P42858 3/20 0.50
KDM4E B2RXH2 3/20 0.50
LMNA P02545 2/20 0.50
HPGD P15428 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
POLB P06746 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CASP1 P29466 1/20 0.50
CYP2C19 P33261 1/20 0.50
CREBBP Q92793 1/20 0.50
MAOA P21397 3/20 0.45
ATM Q13315 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HKDC1 Q2TB90 1/20 0.44
USP8 P40818 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6408125 0.87 KMT2A (0.50) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6407305 0.84 HPGD (0.48) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6407142 0.82 MAPT (0.46) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6407586 0.77 MAPT (0.40) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL7638107 0.77 TOP2A (0.60) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6412752 0.75 HPGD (0.48) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6859938 0.75 MAOA (0.40) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6409833 0.75 MAOA (0.40) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6865846 0.74 MAOA (0.37) MAPTKMT2AMAPK1HTTKDM4E
SCHEMBL6841569 0.74 TOP2A (0.42) MAPTKMT2AMAPK1HTTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP claimed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US claimed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed