SCHEMBL6407772

SCHEMBL6407772

O=C1C=CC(=O)c2c(Cl)ccnc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 4/20 0.44
CDC25B P30305 3/20 0.44
MEN1 O00255 2/20 0.37
THRB P10828 2/20 0.37
BLM P54132 2/20 0.37
KMT2A Q03164 2/20 0.37
USP2 O75604 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
GLA P06280 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
MAPK1 P28482 1/20 0.37
BRCA1 P38398 1/20 0.37
HSD17B10 Q99714 1/20 0.37
DAO P14920 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22580777 0.76 S100A4 (0.41) S100A4CDC25BMEN1THRBBLM
SCHEMBL7179176 0.75 CDC25B (0.44) S100A4CDC25BMEN1THRBBLM
SCHEMBL177682 0.75 CDC25B (0.54) S100A4CDC25BMEN1THRBBLM
SCHEMBL15478974 0.72 S100A4 (0.41) S100A4CDC25BAURKAAURKBCYP1A1
SCHEMBL6597636 0.72 P4HB (0.37) S100A4CDC25BDAOTDP2NSD2
SCHEMBL8663747 0.71 MEN1 (0.50) CDC25BMEN1THRBBLMKMT2A
SCHEMBL6409655 0.71 TOP1 (0.49) S100A4CDC25BMEN1KMT2AUSP2
SCHEMBL13861842 0.69 S100A4 (0.35) S100A4CDC25B
SCHEMBL31511817 0.69 S100A4 (0.54) S100A4CDC25BMEN1THRBBLM
SCHEMBL7719621 0.69 S100A4 (0.54) S100A4CDC25BMEN1THRBBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP disclosed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US disclosed
EP-1202992-B1 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS CEPHALON FRANCE (FR) 2004-09-15 EP disclosed
US-6583150-B1 Cytotoxic propertie; antitumor; pyrido-(3,2-g)quinoline-5,10-diones; benzo(b)pyrido(4,3,2-de)(1,7)-phenanthroline-8-ones LABORATORIE L. LAFON (FR) 2003-06-24 US disclosed
US-6515127-B1 The invention concerns a method for preparing quinoline-5,8-diones of formula (I) light-induced oxygenation of a 8-hydroxyquinoline. and intermediates LABORATOIRE L. LAFON (FR) 2003-02-04 US disclosed
EP-1202972-A2 METHOD FOR PREPARING QUINOLINE-5,8-DIONES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
EP-1202992-A2 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
EP-1161432-A1 PHARMACEUTICAL COMPOSITION BASED ON POLYAROMATIC COMPOUNDS LABORATOIRE L. LAFON (FR) 2001-12-12 EP disclosed
WO-2001012631-A2 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed
WO-2001012597-A2 METHOD FOR PREPARING QUINOLINE-5,8-DIONES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed
WO-2000055160-A1 PHARMACEUTICAL COMPOSITION BASED ON POLYAROMATIC COMPOUNDS LABORATOIRE L. LAFON (FR) 2000-09-21 WO disclosed