SCHEMBL6409655

SCHEMBL6409655

COc1ccnc2c1C(=O)C=CC2=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 1/20 0.49
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
S100A4 P26447 1/20 0.40
CDC25B P30305 1/20 0.40
MAPT P10636 4/20 0.38
KMT2A Q03164 4/20 0.38
KDM4E B2RXH2 4/20 0.38
MAPK1 P28482 3/20 0.38
HTT P42858 3/20 0.38
HPGD P15428 3/20 0.38
LMNA P02545 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CASP1 P29466 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL358094 0.75 TOP1 (0.63) TOP1CA1CA2CA7CA9
SCHEMBL29442957 0.75 TOP1 (0.63) TOP1CA1CA2CA7CA9
Hydrogen Sulfide SCHEMBL28484519 0.73 TOP1 (0.61) TOP1CA1CA2CA7CA9
SCHEMBL15478974 0.72 S100A4 (0.41) S100A4CDC25BTXNRD1TXNRD3TXNRD2
SCHEMBL6407586 0.71 MAPT (0.40) CA1CA2CA7CA9S100A4
SCHEMBL177682 0.71 CDC25B (0.54) TOP1S100A4CDC25BMAPTKMT2A
SCHEMBL6407772 0.71 S100A4 (0.44) S100A4CDC25BMAPTKMT2AMAPK1
SCHEMBL7179176 0.71 CDC25B (0.44) S100A4CDC25BKMT2ATDP1HKDC1
SCHEMBL6414212 0.70 MAPT (0.39) CA1CA2CA9S100A4MAPT
Sulfur Dioxide SCHEMBL28202805 0.70 CA1 (0.57) TOP1CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP disclosed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US disclosed
EP-1202992-B1 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS CEPHALON FRANCE (FR) 2004-09-15 EP disclosed
US-6583150-B1 Cytotoxic propertie; antitumor; pyrido-(3,2-g)quinoline-5,10-diones; benzo(b)pyrido(4,3,2-de)(1,7)-phenanthroline-8-ones LABORATORIE L. LAFON (FR) 2003-06-24 US disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
EP-1202992-A2 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed
WO-2001012631-A2 ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed