SCHEMBL6407904

SCHEMBL6407904

COc1cnc2c(c1C)C(=O)c1c(N(C)C)ccnc1C2=O

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.33
MAPT P10636 3/20 0.33
KDM4E B2RXH2 3/20 0.33
LMNA P02545 3/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
HPGD P15428 2/20 0.33
MAPK1 P28482 2/20 0.33
KMT2A Q03164 2/20 0.33
POLB P06746 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CASP1 P29466 1/20 0.33
CYP2C19 P33261 1/20 0.33
CREBBP Q92793 1/20 0.33
ATM Q13315 1/20 0.33
HKDC1 Q2TB90 1/20 0.33
MAOA P21397 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6414255 0.96 HTT (0.34) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6410278 0.85 MAPT (0.36) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6410373 0.81 MAPT (0.36) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6414247 0.80 MAPT (0.37) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6409035 0.80 HTT (0.42) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6414875 0.77 ALDH1A1 (0.34) HTTMAPTKDM4ELMNAMAPK1
SCHEMBL6408046 0.77 HTT (0.42) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6415962 0.77 MAPT (0.37) HTTMAPTKDM4ELMNASMN1; SMN2
SCHEMBL6407781 0.76 S100A4 (0.50) MAPTKDM4EKMT2ATDP1HKDC1
SCHEMBL6415723 0.73 S100A4 (0.50) KMT2ATDP1HKDC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed