SCHEMBL6409035

SCHEMBL6409035

COc1cnc2c3c(nccc13)-c1c(N(C)C)ccnc1C2=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 5/20 0.42
MAPT P10636 3/20 0.42
KMT2A Q03164 3/20 0.42
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
HPGD P15428 2/20 0.42
MAPK1 P28482 2/20 0.42
ATM Q13315 1/20 0.42
HKDC1 Q2TB90 1/20 0.42
KDM4E B2RXH2 4/20 0.37
POLB P06746 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CASP1 P29466 1/20 0.37
CYP2C19 P33261 1/20 0.37
CREBBP Q92793 1/20 0.37
GRM1 Q13255 6/20 0.36
GRM5 P41594 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6408046 0.90 HTT (0.42) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6409043 0.85 MAPT (0.46) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6407904 0.80 HTT (0.33) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6414255 0.78 HTT (0.34) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6407142 0.78 MAPT (0.46) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6866314 0.77 MAOA (0.37) HTTMAPTKMT2ALMNAHPGD
SCHEMBL6409081 0.75 HKDC1 (0.46) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL7804334 0.74 MAOA (0.53) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL6408548 0.73 TOP2A (0.53) HTTMAPTKMT2ALMNASMN1; SMN2
SCHEMBL7182934 0.72 TERT (0.57) HTTSMN1; SMN2HPGDKDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP disclosed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed