SCHEMBL6407959

SCHEMBL6407959

O=C(CCl)CC(=O)Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.65

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.59
KMT2A Q03164 6/20 0.59
HTT P42858 4/20 0.58
MAPT P10636 4/20 0.58
ALDH1A1 P00352 3/20 0.58
LMNA P02545 3/20 0.55
HSP90AA1 P07900 1/20 0.54
HPGD P15428 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TGM2 P21980 1/20 0.51
POLB P06746 3/20 0.51
NAMPT P43490 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL853676 0.88 MEN1 (0.65) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL6416822 0.87 MEN1 (0.53) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL9018657 0.86 MEN1 (0.71) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL10617946 0.84 NPC1 (0.57) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL14871553 0.84 KMT2A (0.59) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL1429699 0.82 MEN1 (0.65) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL27833966 0.82 ALDH1A1 (0.64) MEN1KMT2AHTTMAPTALDH1A1
4-Nitroaniline SCHEMBL3978656 0.81 ALDH1A1 (0.56) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL23748585 0.80 MEN1 (0.70) MEN1KMT2AHTTMAPTALDH1A1
SCHEMBL10923174 0.80 NPSR1 (0.73) MEN1KMT2AHTTMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed
US-4558158-A Process for the production of 4-(trialkylammonium)-acetoacetarylides LONZA LTD. (CH) 1985-12-10 US disclosed
US-4552983-A Process for the production of 4-(trialkylammonium)-acetoacetarylides LONZA LTD. (CH) 1985-11-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 MEN1 131/4885KMT2A 2739/4885HTT 1370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.