Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853676 | 0.92 | MEN1 (0.65) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL1707504 | 0.85 | RAB9A (0.63) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL23748585 | 0.84 | MEN1 (0.70) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL10923174 | 0.84 | NPSR1 (0.73) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL1311708 | 0.82 | MEN1 (0.82) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL6407959 | 0.81 | MEN1 (0.59) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL31633419 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL9018657 | 0.80 | MEN1 (0.71) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL1429699 | 0.80 | MEN1 (0.65) | ALDH1A1MEN1KMT2AMAPTHTT | |
| SCHEMBL3677488 | 0.79 | MEN1 (0.65) | ALDH1A1MEN1KMT2AMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |