Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | UBE2N | P61088 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20492595 | 0.85 | SMN1; SMN2 (0.43) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL759173 | 0.85 | EGFR (0.52) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL6408208 | 0.82 | ALDH1A1 (0.43) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL2977130 | 0.79 | TNK2 (0.58) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL18341976 | 0.75 | EGFR (0.33) | EGFRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30883354 | 0.72 | EGFR (0.34) | EGFRAURKAKDR | |
| SCHEMBL1787179 | 0.70 | TNK2 (0.58) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL6410337 | 0.70 | ALDH1A1 (0.44) | EGFRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1790077 | 0.70 | ALDH1A1 (0.45) | EGFRAURKAMEN1KMT2AALDH1A1 | |
| SCHEMBL6202986 | 0.70 | ALDH1A1 (0.45) | EGFRAURKAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005092896-A1 | COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2005-10-06 | — | — | WO | disclosed |