Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508113 | 0.82 | CYP3A4 (0.56) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL1220305 | 0.82 | HTR7 (0.49) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL9149358 | 0.82 | HTR7 (0.49) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL4500085 | 0.81 | HTR7 (0.51) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL5159176 | 0.81 | HTR7 (0.51) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL8089068 | 0.81 | ABL1 (0.50) | HTR7ALDH1A1HTT | |
| SCHEMBL5808074 | 0.81 | ABL1 (0.50) | HTR7ALDH1A1HTT | |
| SCHEMBL8206299 | 0.81 | ABL1 (0.50) | HTR7ALDH1A1HTT | |
| SCHEMBL11934987 | 0.81 | HTR7 (0.48) | HTR7CYP3A4TSHRALDH1A1MAPT | |
| SCHEMBL11044690 | 0.81 | ABL1 (0.50) | HTR7ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887895-B2 | Pseudolaric acid-B derivatives, their preparation and pharmaceutical compositions | SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCE (CN) | 2005-05-03 | — | — | US | disclosed |
| US-20040235944-A1 | Novel pseudolaric acid-b derivatives, their preparation and pharmaceutical compositions | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE (CN) | 2004-11-25 | — | — | US | disclosed |
| EP-1418177-A1 | NOVEL PSEUDOLARIC ACID-B DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2004-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235944-A1 | Novel pseudolaric acid-b derivatives, their preparation and pharmaceutical compositions | HCAR1, GRHPR, HCAR2 | HTR7 1782/4885CYP3A4 200/4885TSHR 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.