Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526651 | 0.89 | KEAP1 (0.52) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL5319576 | 0.88 | KEAP1 (0.47) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL4442430 | 0.87 | KEAP1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL9862687 | 0.87 | ALDH1A1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL646005 | 0.85 | KDM4E (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL5419101 | 0.84 | KEAP1 (0.47) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL170765 | 0.82 | KEAP1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL15154484 | 0.82 | KEAP1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL6592729 | 0.82 | KEAP1 (0.59) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL1446165 | 0.82 | KEAP1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014773-A1 | Therapeutic use | ASTRAZENACA AB (SE) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014773-A1 | Therapeutic use | CD4, HLA-DRB1, CD74 | KEAP1 3355/4885SMN1; SMN2 2546/4885HPGD 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.