Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6408905 | 0.99 | MAPK1 (0.44) | MAPK1ALDH1A1MAPTROCK2ROCK1 | |
| SCHEMBL6415545 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MAPTROCK2ROCK1POLB | |
| SCHEMBL6411451 | 0.89 | MAPK1 (0.44) | MAPK1ALDH1A1MAPTROCK2ROCK1 | |
| SCHEMBL6409526 | 0.88 | GAA (0.43) | ALDH1A1ROCK2ROCK1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5254792 | 0.88 | ALDH1A1 (0.47) | ALDH1A1MAPTROCK2ROCK1POLB | |
| Hydrochloric Acid SCHEMBL6412418 | 0.88 | MAPK1 (0.43) | MAPK1ALDH1A1MAPTROCK2ROCK1 | |
| SCHEMBL6416567 | 0.88 | ROCK2 (0.51) | ALDH1A1ROCK2ROCK1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6408289 | 0.88 | GAA (0.43) | ALDH1A1ROCK2ROCK1KMT2AMEN1 | |
| SCHEMBL6409318 | 0.88 | CCR5 (0.45) | MAPK1ALDH1A1MAPTROCK2ROCK1 | |
| SCHEMBL6410424 | 0.87 | ROCK2 (0.52) | ROCK2ROCK1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | MAPK1 1676/4885ALDH1A1 869/4885MAPT 4525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.