Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | VNN1 | O95497 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047191 | 0.90 | LMNA (0.38) | LMNABRD4HDAC3HDAC4HDAC1 | |
| SCHEMBL5050785 | 0.90 | ACACB (0.37) | LMNAVNN1HDAC1ALDH1A1MAPT | |
| SCHEMBL5049705 | 0.87 | PARP10 (0.44) | PARP10SIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL5047000 | 0.87 | VNN1 (0.39) | PARP10VNN1 | |
| SCHEMBL6411049 | 0.87 | PARP10 (0.33) | LMNAPARP10SIRT2SIRT1SIRT3 | |
| SCHEMBL6411995 | 0.87 | HPGD (0.33) | LMNAVNN1ALDH1A1MAPT | |
| SCHEMBL5050793 | 0.84 | BRD4 (0.37) | LMNABRD4HDAC3HDAC4HDAC1 | |
| SCHEMBL5048383 | 0.83 | ACACB (0.36) | LMNAVNN1HDAC1HDAC6 | |
| SCHEMBL5044062 | 0.83 | HDAC1 (0.41) | LMNAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5047199 | 0.82 | BRD4 (0.35) | LMNASIRT2SIRT1SIRT3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513803-A1 | LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS | Galderma Research & Development, S.N.C. (FR) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101945-A1 | LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2003-12-11 | — | — | WO | disclosed |