Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HPN | P05981 | 3/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409170 | 0.88 | TP53 (0.47) | TP53HPNST14KMT2APLAU | |
| SCHEMBL6412715 | 0.87 | TP53 (0.56) | TP53HPNST14KMT2APLAU | |
| SCHEMBL6409841 | 0.87 | TP53 (0.46) | TP53HPNST14KMT2APLAU | |
| SCHEMBL2581171 | 0.81 | TP53 (0.49) | TP53HPNST14KMT2APLAU | |
| SCHEMBL2403293 | 0.80 | ALDH1A1 (0.48) | TP53HPNST14KMT2APLAU | |
| SCHEMBL22500544 | 0.77 | KMT2A (0.70) | TP53HPNST14KMT2APLAU | |
| SCHEMBL22500546 | 0.77 | KMT2A (0.70) | TP53HPNST14KMT2APLAU | |
| SCHEMBL2847465 | 0.73 | TP53 (0.54) | TP53HPNST14KMT2APLAU | |
| SCHEMBL6409700 | 0.71 | TSHR (0.47) | KMT2AALDH1A1MAPK1 | |
| SCHEMBL20335146 | 0.71 | CTSL (0.67) | KMT2AMMP9ALDH1A1MEN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |