Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411568 | 0.85 | MAPT (0.50) | KMT2AMEN1RAB9APKMPOLB | |
| SCHEMBL2405235 | 0.84 | KMT2A (0.55) | KMT2AMEN1RAB9APKMPOLB | |
| SCHEMBL6410174 | 0.84 | ALDH1A1 (0.50) | KMT2AMEN1RAB9APKMPOLB | |
| SCHEMBL6417720 | 0.83 | ALDH1A1 (0.58) | KMT2AMEN1POLBALDH1A1MAPK1 | |
| SCHEMBL6411079 | 0.83 | LMNA (0.44) | KMT2APKMPOLBALDH1A1MAPK1 | |
| SCHEMBL6410840 | 0.80 | ALDH1A1 (0.43) | KMT2AMEN1RAB9APKMALDH1A1 | |
| SCHEMBL6411124 | 0.80 | ALDH1A1 (0.56) | KMT2AMEN1RAB9APKMPOLB | |
| SCHEMBL6412249 | 0.80 | JAK2 (0.43) | KMT2AMEN1ALDH1A1MAPK1GAA | |
| SCHEMBL6410871 | 0.79 | ALDH1A1 (0.53) | KMT2AMEN1RAB9APKMPOLB | |
| SCHEMBL6409449 | 0.78 | CYP2C19 (0.49) | KMT2AMEN1PKMPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |