Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417412 | 0.87 | ATM (0.51) | GAAHTTNPSR1ALDH1A1KMT2A | |
| SCHEMBL6417720 | 0.86 | ALDH1A1 (0.58) | MAPK1MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL6409583 | 0.84 | MAPK1 (0.46) | JAK2JAK1MAPK1GAAHTT | |
| SCHEMBL6410302 | 0.83 | SMN1; SMN2 (0.58) | MAPK1GAAHTTMEN1ALDH1A1 | |
| SCHEMBL6411079 | 0.82 | LMNA (0.44) | MAPK1GAAHTTNPSR1ALDH1A1 | |
| SCHEMBL6409948 | 0.81 | KDM4E (0.47) | MAPK1GAAHTTNPSR1ALDH1A1 | |
| SCHEMBL6410504 | 0.80 | MEN1 (0.49) | MAPK1HTTMEN1ALDH1A1KMT2A | |
| SCHEMBL6411430 | 0.80 | RAB9A (0.47) | JAK2JAK1GAAHTTMEN1 | |
| SCHEMBL6409878 | 0.80 | KMT2A (0.52) | JAK2MAPK1GAAMEN1ALDH1A1 | |
| SCHEMBL6409700 | 0.79 | TSHR (0.47) | JAK2JAK1MAPK1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |