Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409921 | 0.88 | TRPV1 (0.48) | ALDH1A1GAAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL2402452 | 0.86 | ALDH1A1 (0.51) | ALDH1A1GAAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL6409851 | 0.84 | SMN1; SMN2 (0.42) | ALDH1A1GAAPOLBSMN1; SMN2LMNA | |
| SCHEMBL6411481 | 0.83 | POLB (0.44) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL6411660 | 0.80 | PKM (0.51) | ALDH1A1GAAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL6415335 | 0.78 | TSHR (0.44) | ALDH1A1GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6409449 | 0.78 | CYP2C19 (0.49) | ALDH1A1GAAPOLBSMN1; SMN2MEN1 | |
| SCHEMBL6409805 | 0.77 | NPSR1 (0.41) | ALDH1A1GAAMEN1KMT2ALMNA | |
| SCHEMBL6409429 | 0.76 | LMNA (0.41) | ALDH1A1GAAPOLBSMN1; SMN2KMT2A | |
| SCHEMBL6411124 | 0.76 | ALDH1A1 (0.56) | ALDH1A1GAAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |
| EP-1401841-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003000699-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2003-01-03 | — | — | WO | disclosed |