Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 8/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 10/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166994 | 0.87 | CYP11B2 (0.46) | CYP11B2CYP11B1CACNA1HFNTAFNTB | |
| SCHEMBL6452310 | 0.82 | CYP11B1 (0.46) | CYP11B2CYP11B1CACNA1HFNTAFNTB | |
| Bromide SCHEMBL7629321 | 0.81 | CYP11B1 (0.45) | CYP11B2CYP11B1CACNA1HFNTAFNTB | |
| SCHEMBL7704754 | 0.81 | CYP11B1 (0.45) | CYP11B2CYP11B1CACNA1HFNTAFNTB | |
| SCHEMBL7971164 | 0.81 | CYP11B1 (0.52) | CYP11B2CYP11B1CACNA1H | |
| SCHEMBL7818410 | 0.80 | CYP11B1 (0.70) | CYP11B2CYP11B1FNTAFNTB | |
| SCHEMBL7709344 | 0.80 | CYP11B1 (0.51) | CYP11B2CYP11B1CACNA1H | |
| SCHEMBL6433915 | 0.79 | CYP11B1 (0.64) | CYP11B2CYP11B1CACNA1H | |
| SCHEMBL4724498 | 0.79 | CYP11B1 (0.43) | CYP11B2CYP11B1CACNA1H | |
| SCHEMBL6708657 | 0.78 | CYP11B1 (0.72) | CYP11B2CYP11B1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |