Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6410281 | 0.99 | HDAC11 (0.37) | HDAC11KCNA3CXCR3MEN1KMT2A | |
| SCHEMBL6417273 | 0.93 | HDAC11 (0.37) | HDAC11ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL6410226 | 0.92 | ROCK2 (0.43) | HDAC11CXCR3MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL6417268 | 0.92 | HDAC11 (0.37) | HDAC11ALDH1A1MAPTLMNAPOLB | |
| Hydrochloric Acid SCHEMBL6410218 | 0.92 | ROCK2 (0.42) | HDAC11CXCR3MEN1KMT2ALMNA | |
| SCHEMBL6409153 | 0.92 | MEN1 (0.42) | MEN1KMT2AALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL6409150 | 0.91 | MEN1 (0.41) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL6409128 | 0.90 | CCR5 (0.46) | LMNASMN1; SMN2CCR5NPSR1 | |
| SCHEMBL6412682 | 0.90 | DRD2 (0.37) | HDAC11ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL6409935 | 0.90 | HDAC11 (0.37) | HDAC11ROCK2ROCK1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | HDAC11 431/4885KCNA3 2165/4885CXCR3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.