Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | DNAJA1 | P31689 | 1/20 | 0.31 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411440 | 0.89 | FNTA (0.33) | HTR1AFNTAPGGT1BFNTBDNAJA1 | |
| SCHEMBL6409378 | 0.88 | HTR1A (0.35) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL7166236 | 0.86 | FNTA (0.37) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL7165181 | 0.81 | FNTA (0.37) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL6411741 | 0.77 | FNTA (0.34) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL7163140 | 0.76 | FNTA (0.46) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL7168685 | 0.76 | FNTA (0.47) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL6412093 | 0.73 | FNTA (0.35) | HTR1AHTR1DHTR1BFNTAPGGT1B | |
| SCHEMBL6523879 | 0.73 | FNTA (0.62) | FNTAPGGT1BFNTB | |
| SCHEMBL6526286 | 0.72 | FNTA (0.49) | HTR1AHTR1DHTR1BFNTAPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |