Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 5/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.33 |
| ▸ | FNTB | P49356 | 4/20 | 0.33 |
| ▸ | DNAJA1 | P31689 | 1/20 | 0.33 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410632 | 0.89 | HTR1A (0.35) | FNTAPGGT1BFNTBDNAJA1HTR1A | |
| SCHEMBL6411741 | 0.86 | FNTA (0.34) | FNTAPGGT1BFNTBDNAJA1GPR52 | |
| SCHEMBL6409378 | 0.76 | HTR1A (0.35) | FNTAPGGT1BFNTBDNAJA1HTR1A | |
| SCHEMBL6412093 | 0.74 | FNTA (0.35) | FNTAPGGT1BFNTBDNAJA1GPR52 | |
| SCHEMBL7166236 | 0.74 | FNTA (0.37) | FNTAPGGT1BFNTBDNAJA1GPR52 | |
| SCHEMBL7161933 | 0.74 | FNTA (0.40) | FNTAPGGT1BFNTBDNAJA1GPR52 | |
| SCHEMBL7168181 | 0.72 | FNTA (0.41) | FNTAPGGT1BFNTBDNAJA1GPR52 | |
| SCHEMBL7165208 | 0.70 | FNTA (0.33) | FNTAPGGT1BFNTBDNAJA1HTR5A | |
| SCHEMBL7164493 | 0.70 | FNTA (0.54) | FNTAPGGT1BFNTBDNAJA1 | |
| SCHEMBL6416010 | 0.69 | FNTA (0.33) | FNTAPGGT1BFNTBDNAJA1GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |