Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415977 | 0.90 | ABL1 (0.41) | USP7SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6409445 | 0.85 | USP7 (0.36) | USP7SMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL2401319 | 0.85 | SMN1; SMN2 (0.41) | USP7SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6411592 | 0.84 | POLB (0.41) | ALDH1A1HPGDRAB9APOLBLMNA | |
| SCHEMBL6416282 | 0.84 | HTR1A (0.43) | — | |
| SCHEMBL6411043 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1HPGDRAB9AMETAP2 | |
| SCHEMBL6410215 | 0.81 | SLC6A7 (0.42) | SMN1; SMN2ALDH1A1MEN1KMT2ASLC6A7 | |
| SCHEMBL6431092 | 0.81 | AVPR1A (0.41) | SMN1; SMN2ALDH1A1HTTPOLBMETAP2 | |
| SCHEMBL6410959 | 0.80 | GAA (0.36) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL6409843 | 0.79 | CYP3A4 (0.47) | ALDH1A1MEN1KMT2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |