SCHEMBL6410985

SCHEMBL6410985

CC(C)Oc1ccc(Br)cc1CN1CCC(=O)C(C(c2ccccc2)c2ccccc2)C1

nearest known ligand 0.68

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6407881 0.81 TACR1 (1.00) TACR1
SCHEMBL6410360 0.80 TACR1 (0.82) TACR1
SCHEMBL6407978 0.80 TACR1 (0.64) TACR1
SCHEMBL6405931 0.79 TACR1 (0.82) TACR1
SCHEMBL6410689 0.79 TACR1 (1.00) TACR1
SCHEMBL6408899 0.78 TACR1 (0.98) TACR1
SCHEMBL6411916 0.78 TACR1 (0.76) TACR1
Hydrochloric Acid SCHEMBL6406251 0.78 TACR1 (1.00) TACR1
SCHEMBL6408869 0.77 TACR1 (0.85) TACR1
SCHEMBL6406086 0.76 TACR1 (0.75) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190175475-A1 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS THE PROCTER & GAMBLE COMPANY 2019-06-13 US disclosed
US-8541466-B2 Compositions and methods for treating hair loss using non-naturally occurring prostaglandins DUKE UNIVERSITY (US) 2013-09-24 US disclosed
US-20050222232-A1 prostaglandin F analogs, such as 13,14-dihydro-15-(2-benzathiozolyl) pentanor Prostaglandin F1 alpha, with other hair growth stimulant; topically to the skin; can arrest hair loss, reverse hair loss, and promote hair growth; cosmetics DUKE UNIVERSITY 2005-10-06 US disclosed
US-20050038072-A1 Nitrogeneous cyclic ketone derivative, process for producing the same, and use TAKEDA CHEMICAL INDUSTRIES, LTD. 2005-02-17 US disclosed
EP-1460062-A1 NITROGENOUS CYCLIC KETONE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE Takeda Chemical Industries, Ltd. (JP) 2004-09-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190175475-A1 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS PTGES, PTGS1, PTGS2 TACR1 1695/4885
US-20050222232-A1 prostaglandin F analogs, such as 13,14-dihydro-15-(2-benzathiozolyl) pentanor Prostaglandin F1 alpha, with other hair growth stimulant; topically to the skin; can arrest hair loss, reverse hair loss, and promote hair growth; cosmetics PTGIR, PTGDR, PTGS1 TACR1 434/4885
US-20050038072-A1 Nitrogeneous cyclic ketone derivative, process for producing the same, and use BDKRB1, BDKRB2, TACR1 TACR1 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.