Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6416109 | 0.92 | GAA (0.48) | GAACYP1A2ABCG2KDM4EALDH1A1 | |
| SCHEMBL6441331 | 0.82 | SIRT2 (0.41) | GAACYP1A2ABCG2KDM4EALDH1A1 | |
| SCHEMBL6417625 | 0.80 | ALDH1A1 (0.44) | ADORA3GAACYP1A2CYP2C19ABCG2 | |
| SCHEMBL1948138 | 0.79 | TERT (0.44) | — | |
| SCHEMBL6417593 | 0.78 | TSHR (0.46) | CYP1A2CYP2C19ABCG2KDM4EALDH1A1 | |
| SCHEMBL6418917 | 0.77 | GAA (0.44) | GAAKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15162401 | 0.77 | TERT (0.42) | — | |
| SCHEMBL18510101 | 0.76 | TERT (0.41) | — | |
| SCHEMBL6414089 | 0.75 | GAA (0.42) | GAAKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1517541 | 0.75 | ABCG2 (0.42) | GAAABCG2KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071474-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6479477-B1 | SUITABLE FOR USE IN MODULATING INTRA- AND EXTRACELLULAR PROCESSES IN WHICH SUPEROXIDE RADICALS, OR OTHER OXIDANTS SUCH AS HYDROGEN PEROXIDE OR PEROXYNITRITE, ARE A PARTICIPANT | DUKE UNIVERSITY | 2002-11-12 | — | — | US | disclosed |
| EP-1071474-A4 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2002-10-24 | — | — | EP | disclosed |
| EP-1071474-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999055388-A9 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2000-01-27 | — | — | WO | disclosed |
| WO-1999055388-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 1999-11-04 | — | — | WO | disclosed |