Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.32 |
| ▸ | DRD2 | P14416 | 9/20 | 0.32 |
| ▸ | HTR2A | P28223 | 9/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | HRH2 | P25021 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009019 | 0.90 | GPR52 (0.35) | HTR1ADRD2HTR2AKCNH2MCHR1 | |
| SCHEMBL6412080 | 0.83 | FNTA (0.44) | FNTAPGGT1B | |
| SCHEMBL6430353 | 0.73 | FNTA (0.48) | FNTAPGGT1B | |
| SCHEMBL6412396 | 0.70 | SIRT2 (0.33) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| SCHEMBL7247790 | 0.66 | HTR5A (0.38) | HTR1ADRD2HTR2AKCNH2HTR2C | |
| Hydrochloric Acid SCHEMBL7247789 | 0.66 | HTR5A (0.38) | HTR1ADRD2HTR2AKCNH2HTR7 | |
| SCHEMBL6417857 | 0.62 | HTR2A (0.42) | HTR1ADRD2HTR2AKCNH2SLC6A4 | |
| Hydrochloric Acid SCHEMBL8175209 | 0.61 | FNTA (0.58) | FNTAPGGT1B | |
| SCHEMBL7715094 | 0.60 | PSEN1 (0.33) | — | |
| SCHEMBL3519558 | 0.56 | FNTA (0.58) | FNTAPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |