Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mometasone Furoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 5/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.84 |
| ▸ | PGR | P06401 | 6/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.84 |
| ▸ | LMNA | P02545 | 3/20 | 0.84 |
| ▸ | AR | P10275 | 3/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.84 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.84 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.84 |
| ▸ | USP2 | O75604 | 5/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | MLNR | O43193 | 1/20 | 0.77 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.77 |
| ▸ | PPARG | P37231 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037205 | 0.92 | NR3C1 (0.83) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL7436523 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL12996648 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL2594997 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL8430908 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL25382496 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL4896227 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL600107 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL4568 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA | |
| Mometasone Furoate SCHEMBL13026146 | 0.92 | CYP3A4 (1.00) | CYP3A4PGRNR3C1ADORA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245497-A1 | Treatment of ophthalmic conditions | EYE CO PTY LTD (AU) | 2005-11-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245497-A1 | Treatment of ophthalmic conditions | MC2R, NR3C2, PTGIR | NR3C1 6/4885CYP3A4 4201/4885PGR 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.