Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.59 |
| ▸ | MMP13 | P45452 | 5/20 | 0.59 |
| ▸ | MMP9 | P14780 | 4/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6290612 | 0.91 | MMP1 (0.71) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6290776 | 0.91 | MMP1 (0.56) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL7151568 | 0.91 | MMP1 (0.61) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6293913 | 0.89 | MMP1 (0.56) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6289426 | 0.87 | MMP1 (0.58) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6293288 | 0.85 | MMP9 (0.81) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL6293214 | 0.84 | MMP1 (0.47) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6290764 | 0.82 | MMP1 (0.75) | MMP1MMP13MMP9ADAM17NR3C1 | |
| SCHEMBL6290784 | 0.82 | MMP1 (0.68) | MMP1MMP13MMP9ADAM17LMNA | |
| SCHEMBL6293912 | 0.80 | NR3C1 (0.50) | MMP1MMP13MMP9ADAM17NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946473-B2 | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors | WYETH HOLDINGS CORPORATION (US) | 2005-09-20 | — | — | US | disclosed |