Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 3/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415761 | 0.71 | SMN1; SMN2 (0.39) | S100A4SMN1; SMN2TP53CYP3A4HPGD | |
| SCHEMBL15478974 | 0.70 | S100A4 (0.41) | S100A4CDC25B | |
| SCHEMBL6409853 | 0.70 | S100A4 (0.41) | S100A4SMN1; SMN2TP53CYP3A4HPGD | |
| SCHEMBL6407772 | 0.69 | S100A4 (0.44) | S100A4CDC25BTP53CYP3A4HPGD | |
| SCHEMBL177682 | 0.69 | CDC25B (0.54) | S100A4CDC25BTP53CYP3A4HPGD | |
| SCHEMBL7179176 | 0.69 | CDC25B (0.44) | S100A4CDC25BKMT2AMEN1TDP1 | |
| SCHEMBL30408893 | 0.67 | S100A4 (0.63) | S100A4CDC25BSMN1; SMN2TP53CYP3A4 | |
| SCHEMBL7625099 | 0.67 | S100A4 (0.63) | S100A4CDC25BSMN1; SMN2TP53CYP3A4 | |
| SCHEMBL6409655 | 0.66 | TOP1 (0.49) | S100A4CDC25BSMN1; SMN2CYP3A4HPGD | |
| SCHEMBL11409834 | 0.65 | S100A4 (0.64) | S100A4TP53CYP3A4HIF1ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202993-B1 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LAFON LABOR (FR) | 2005-10-19 | — | — | EP | disclosed |
| US-6809096-B1 | SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS | LABORATOIRE L. LAFON (FR) | 2004-10-26 | — | — | US | disclosed |
| US-6583150-B1 | Cytotoxic propertie; antitumor; pyrido-(3,2-g)quinoline-5,10-diones; benzo(b)pyrido(4,3,2-de)(1,7)-phenanthroline-8-ones | LABORATORIE L. LAFON (FR) | 2003-06-24 | — | — | US | disclosed |
| EP-1202993-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| EP-1161432-A1 | PHARMACEUTICAL COMPOSITION BASED ON POLYAROMATIC COMPOUNDS | LABORATOIRE L. LAFON (FR) | 2001-12-12 | — | — | EP | disclosed |
| WO-2001012632-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |
| WO-2000055160-A1 | PHARMACEUTICAL COMPOSITION BASED ON POLYAROMATIC COMPOUNDS | LABORATOIRE L. LAFON (FR) | 2000-09-21 | — | — | WO | disclosed |