Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.63 |
| ▸ | HTR2B | P41595 | 4/20 | 0.63 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.49 |
| ▸ | STK17B | O94768 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6408957 | 0.89 | HTR2C (0.61) | HTR2CHTR2BKDREPHB4EPHA2 | |
| SCHEMBL7010009 | 0.81 | HTR2C (0.49) | HTR2CHTR2BKDREPHB4EPHA2 | |
| SCHEMBL6408323 | 0.77 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL19089351 | 0.77 | ALDH1A1 (0.59) | HTR2CHTR2BKDREPHB4EPHA2 | |
| SCHEMBL6413627 | 0.76 | UTS2R (0.57) | HTR2CKDREGFRHTR2AACHE | |
| SCHEMBL906987 | 0.76 | KDR (1.00) | KDREPHB4EPHA2EGFRCIT | |
| SCHEMBL6483193 | 0.76 | KDR (0.57) | HTR2CHTR2BKDREPHB4EPHA2 | |
| SCHEMBL6408213 | 0.76 | HTR2C (0.55) | HTR2CHTR2BKDREPHB4EPHA2 | |
| SCHEMBL12409038 | 0.75 | SYK (0.71) | HTR2CHTR2BHTR2AALDH1A1KDM4E | |
| SCHEMBL13791083 | 0.75 | SYK (0.59) | HTR2CHTR2BHTR2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154028-A1 | Cyclic urea derivatives with 5-ht2c receptor activity | GLAXO GROUP LIMITED (GB) | 2005-07-14 | — | — | US | disclosed |
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154028-A1 | Cyclic urea derivatives with 5-ht2c receptor activity | HTR2C, HTR3C, HTR5A | HTR2C 1/4885HTR2B 28/4885KDR 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.