SCHEMBL6415598

SCHEMBL6415598

CCNC(=O)Nc1cncc(N2CCN(CCOC(=O)Nc3ccccc3OCC)CC2)n1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 3/20 0.43
POLB P06746 2/20 0.43
TP53 P04637 1/20 0.43
BLM P54132 1/20 0.43
HTR3E A5X5Y0 1/20 0.41
HTR3B O95264 1/20 0.41
HTR3A P46098 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41
USP2 O75604 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41
LMNA P02545 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5658252 0.80 ALDH1A1 (0.59) KDM4EMEN1KMT2ASMN1; SMN2USP2
SCHEMBL14457609 0.79 HTT (0.47) KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL14457591 0.79 HTR1A (0.48) KDM4ESMN1; SMN2MAPTPOLBTP53
SCHEMBL14457595 0.79 MAPT (0.45) KDM4EMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL5655919 0.79 KMT2A (0.53) KDM4EMEN1KMT2ASMN1; SMN2MAPT
SCHEMBL5657766 0.78 HRH3 (0.56) KDM4EMEN1KMT2ASMN1; SMN2TP53
SCHEMBL5657914 0.78 POLB (0.50) KDM4EPOLBLMNATDP1
SCHEMBL5659559 0.78 HTR4 (0.50) MEN1KMT2ASMN1; SMN2MAPTPOLB
SCHEMBL6707387 0.78 HTR4 (0.51) KMT2ASMN1; SMN2MAPTPOLBTP53
SCHEMBL5655982 0.78 MAPT (0.49) KDM4EKMT2ASMN1; SMN2MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050267126-A1 Compounds derived from aryl carbamates, preparation thereof and uses of same CEREP (FR) 2005-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050267126-A1 Compounds derived from aryl carbamates, preparation thereof and uses of same HTR4, HTR2B, HTR1B KDM4E 277/4885MEN1 3108/4885KMT2A 1571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.