Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | OXTR | P30559 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31513481 | 0.94 | MAOA (0.39) | MAOAMAOBLMNAGAAOXTR | |
| SCHEMBL8925 | 0.94 | MAOA (0.39) | MAOAMAOBLMNAGAAOXTR | |
| Water SCHEMBL15284972 | 0.92 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Hydrochloric Acid SCHEMBL8707066 | 0.92 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| Hydrochloric Acid SCHEMBL8699855 | 0.92 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| SCHEMBL7679301 | 0.92 | MAOA (0.38) | MAOAMAOBGAAOXTRABCG2 | |
| SCHEMBL2597639 | 0.86 | MAOA (0.34) | MAOAMAOB | |
| Carbamic Acid SCHEMBL6649969 | 0.85 | HSD17B10 (0.34) | MAOAMAOBKDM4ENPC1ALDH1A1 | |
| SCHEMBL8699302 | 0.84 | NR3C1 (0.32) | MAOAMAOBKDM4ENPC1ALDH1A1 | |
| Phosphoric Acid SCHEMBL4902131 | 0.83 | ACP3 (0.33) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919334-B2 | Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine | WYETH (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040127493-A1 | Antidepressant azaheterocyclylmethyl derivatives of 4,5-dihydroimidazo[1,4,5-de ][1,4]benzoxazine | WYETH | 2004-07-01 | — | — | US | disclosed |
| WO-2004024736-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 4,5-DIHYDROIMIDAZO[1,4,5-DE]BENZOXAZINE | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127493-A1 | Antidepressant azaheterocyclylmethyl derivatives of 4,5-dihydroimidazo[1,4,5-de ][1,4]benzoxazine | CYP19A1, HTR5A, HSD17B11 | MAOA 152/4885MAOB 159/4885KDM4E 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.