SCHEMBL641581

SCHEMBL641581

Cc1sc(N)c(C#N)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM6 O15303 1/20 0.52
ALDH1A1 P00352 10/20 0.46
HSD17B10 Q99714 3/20 0.46
MAPK1 P28482 2/20 0.46
TSHR P16473 1/20 0.46
HPGD P15428 3/20 0.46
HTT P42858 2/20 0.46
MAPT P10636 5/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ADORA2A P29274 1/20 0.42
IKBKB O14920 1/20 0.41
BPTF Q12830 2/20 0.39
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38
CISD2 Q8N5K1 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
POLB P06746 1/20 0.37
PABPC1 P11940 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10308584 0.81 ALDH1A1 (0.44) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL623186 0.79 GRM6 (0.50) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL9486405 0.77 ALDH1A1 (0.41) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL9487470 0.77 ALDH1A1 (0.41) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL12111251 0.77 ALDH1A1 (0.50) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL1720717 0.74 ALDH1A1 (0.46) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL1621985 0.74 ALDH1A1 (0.49) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL11064868 0.73 BPTF (0.48) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL10298787 0.73 GRM6 (0.45) GRM6ALDH1A1HSD17B10MAPK1TSHR
SCHEMBL1622057 0.73 ADORA2A (0.48) GRM6ALDH1A1HSD17B10MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4134083-A None JP disclosed
EP-4719369-A2 INHIBITORS OF FATTY ACID BINDING PROTEINS (FABPS), METHODS OF USE AND METHODS OF MAKING Celloram, Inc. (US) 2026-04-08 EP disclosed
EP-4714456-A2 POLYCYCLIC COMPOUNDS FOR INHIBITING RNA HELICASE DHX33 AND USE THEREOF Shenzhen Keye Life Technologies, Co., Ltd. (CN) 2026-03-25 EP disclosed
WO-2025151311-A1 NICOTINAMIDE DERIVATIVES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-07-17 WO disclosed
WO-2024254161-A2 INHIBITORS OF FATTY ACID BINDING PROTEINS (FABPS), METHODS OF USE AND METHODS OF MAKING CELLORAM INC. (US) 2024-12-12 WO disclosed
CN-118541359-A Inhibitors of molluscum contagiosum infection and methods of use thereof 宾夕法尼亚大学董事会 2024-08-23 CN disclosed
EP-4408833-A1 INHIBITORS OF MOLLUSCUM CONTAGIOSUM INFECTION AND METHODS USING THE SAME The Trustees of The University of Pennsylvania (US) 2024-08-07 EP disclosed
CN-112538078-B Polycyclic compound for inhibiting DHX33 helicase 成都开悦生命科技有限公司 2024-03-19 CN disclosed
US-20230146233-A1 A CLASS OF POLYCYCLIC COMPOUNDS INHIBITING RNA HELICASE DHX33 AND THE APPLICATION THEREOF SHENZHEN KEYE LIFE TECHNOLOGIES, CO., LTD (CN) 2023-05-11 US disclosed
US-20230146233-A1 A CLASS OF POLYCYCLIC COMPOUNDS INHIBITING RNA HELICASE DHX33 AND THE APPLICATION THEREOF SHENZHEN KEYE LIFE TECHNOLOGIES, CO., LTD (CN) 2023-05-11 US disclosed
US-4831013-A BENZODIAZEPINE RECEPTOR ANTAGONISTS CIBA-GEIGY CORPORATION (US) 1989-05-16 US disclosed
WO-1988002370-A1 2-SUBSTITUTED-E-FUSED-[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINES PHARMACEUTICAL COMPOSITIONS AND USES THEREOF CIBA-GEIGY AG (CH) 1988-04-07 WO disclosed
EP-0263071-A1 2-Substituted-e-fused-[1,2,4]-triazolo[1,5-c] pyrimidines, pharmaceutical compositions, and uses thereof CIBA-GEIGY AG (CH) 1988-04-06 EP disclosed
US-4692461-A PLANT PROTECTION BAYER AKTIENGESELLSCHAFT (DE) 1987-09-08 US disclosed
EP-0224140-A1 Thienyl urea derivatives BAYER AG (DE) 1987-06-03 EP disclosed
EP-0217748-A2 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof CIBA-GEIGY AG (CH) 1987-04-08 EP disclosed
EP-0062200-B1 DISAZO DYESTUFFS BASF Aktiengesellschaft (DE) 1985-01-23 EP disclosed
EP-0062200-A1 Disazo dyestuffs BASF Aktiengesellschaft (DE) 1982-10-13 EP disclosed
EP-0037465-A2 Amino azo compounds BASF Aktiengesellschaft (DE) 1981-10-14 EP disclosed
US-3953468-A ALLERGIES THE UPJOHN COMPANY (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230146233-A1 A CLASS OF POLYCYCLIC COMPOUNDS INHIBITING RNA HELICASE DHX33 AND THE APPLICATION THEREOF DHX36, DDX21, DDX3X GRM6 2421/4885ALDH1A1 1988/4885HSD17B10 1299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.