Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415969 | 0.89 | PARP10 (0.47) | S1PR1S1PR3ACACBSLC2A1FLT3 | |
| SCHEMBL6416577 | 0.89 | PIM1 (0.51) | S1PR1S1PR3ACACBSLC2A1FLT3 | |
| SCHEMBL6414486 | 0.81 | FLT3 (0.43) | ACACBFLT3PIM1SLC6A2SLC6A4 | |
| SCHEMBL17338649 | 0.78 | PARP10 (0.52) | S1PR1S1PR3FLT3PARP10PARP15 | |
| SCHEMBL6421505 | 0.77 | CYP1A2 (0.53) | — | |
| SCHEMBL6414370 | 0.76 | PIM1 (0.47) | S1PR1S1PR3FLT3PARP10PARP15 | |
| SCHEMBL6418974 | 0.75 | ITGB3 (0.53) | XDH | |
| SCHEMBL15623106 | 0.74 | MAOB (0.53) | S1PR1S1PR3FLT3KCNH2 | |
| SCHEMBL4809717 | 0.74 | ACACB (0.45) | ACACBSLC2A1PARP10PARP15PARP2 | |
| SCHEMBL12848659 | 0.74 | MAOB (0.52) | S1PR1S1PR3FLT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005118584-A2 | SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | AXYS PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |