Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | GCKR | Q14397 | 7/20 | 0.38 |
| ▸ | GCK | P35557 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309128 | 0.91 | PDE2A (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL6411414 | 0.91 | PDE2A (0.46) | SPRALDH1A1PDE2A | |
| SCHEMBL310170 | 0.90 | HTT (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL309774 | 0.90 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL310204 | 0.88 | CCR6 (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL309343 | 0.85 | SPR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3770851 | 0.85 | SPR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL309552 | 0.85 | SPR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10042205 | 0.81 | TSHR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL10042206 | 0.79 | TSHR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313413-B1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | CONVERGENCE PHARMACEUTICALS (GB) | 2012-05-16 | — | — | EP | disclosed |