Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11779341 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HSD17B10KMT2AMEN1CA2 | |
| SCHEMBL227238 | 0.79 | SMN1; SMN2 (0.59) | ALDH1A1HSD17B10LCKFYNKMT2A | |
| SCHEMBL8700100 | 0.77 | TSHR (0.50) | ALDH1A1CA12CA1CA2CA3 | |
| SCHEMBL4649906 | 0.76 | ALDH1A1 (0.71) | ALDH1A1HSD17B10LCKFYNKMT2A | |
| SCHEMBL20430157 | 0.75 | HSD17B10 (0.45) | ALDH1A1HSD17B10LCKFYNKMT2A | |
| SCHEMBL6409631 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1CA12CA2 | |
| SCHEMBL26343209 | 0.75 | DTYMK (0.51) | ALDH1A1KMT2AMEN1TDP1TSHR | |
| SCHEMBL4649128 | 0.75 | TSHR (0.60) | ALDH1A1HSD17B10KMT2AMEN1PKM | |
| SCHEMBL7084281 | 0.74 | SMN1; SMN2 (0.54) | ALDH1A1HSD17B10KMT2AMEN1PTPN1 | |
| SCHEMBL17202484 | 0.74 | LMNA (0.64) | ALDH1A1HSD17B10LCKFYNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |