SCHEMBL641703

SCHEMBL641703

COC(=O)c1cccc(N(C)C)c1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.58
MAPT P10636 5/20 0.58
ALDH1A1 P00352 5/20 0.58
RAB9A P51151 3/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
TSHR P16473 2/20 0.53
LOXL2 Q9Y4K0 1/20 0.53
LMNA P02545 4/20 0.53
POLB P06746 2/20 0.53
HSD17B10 Q99714 3/20 0.52
HPGD P15428 3/20 0.52
CYP4F2 P78329 1/20 0.51
CYP4A11 Q02928 1/20 0.51
NPC1 O15118 1/20 0.51
GFER P55789 1/20 0.51
ALOX15 P16050 1/20 0.51
KMT2A Q03164 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
NPSR1 Q6W5P4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30444224 1.00 KDM4E (0.58) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL31307550 0.87 KMT2A (0.51) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL9854041 0.87 KMT2A (0.51) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL28110864 0.86 RAB9A (0.60) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL28275103 0.86 TSHR (0.50) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL19633270 0.85 TSHR (0.53) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL5608478 0.84 TSHR (0.58) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL1180585 0.84 KDM4E (0.49) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL19675681 0.84 KDM4E (0.50) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2
SCHEMBL1574197 0.83 LOXL2 (0.51) KDM4EMAPTALDH1A1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184520-A Biphenyl amine compound, preparation method thereof and application thereof in flow battery 中国科学院大连化学物理研究所 2024-06-14 CN claimed
EP-1786552-A1 METHOD OF MAKING POLYMER MONOLITH COMPOSITE SUBSTRATE AND RESULTING SUBSTRATE AS WELL AS BEADS AND BEAD ARRAY Applera Corporation (US) 2007-05-23 EP claimed
WO-2006026378-A1 METHOD OF MAKING POLYMER MONOLITH COMPOSITE SUBSTRATE AND RESULTING SUBSTRATE AS WELL AS BEADS AND BEAD ARRAY APPLERA CORPORATION (US) 2006-03-09 WO claimed
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2026-01-22 US disclosed
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2025-07-29 US disclosed
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof NEXYS THERAPEUTICS, INC. (US) 2024-12-17 US disclosed
EP-4472953-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF Nexys Therapeutics, Inc. (US) 2024-12-11 EP disclosed
US-20240383868-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-11-21 US disclosed
US-20240326503-A1 ON-PRESS DEVELOPMENT TYPE LITHOGRAPHIC PRINTING PLATE PRECURSOR, METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE, LITHOGRAPHIC PRINTING METHOD, AND COMPOUND FUJIFILM CORPORATION (JP) 2024-10-03 US disclosed
EP-4438300-A1 ON-PRESS DEVELOPMENT TYPE LITHOGRAPHIC PRINTING PLATE PRECURSOR, METHOD OF PREPARING LITHOGRAPHIC PRINTING PLATE, LITHOGRAPHIC PRINTING METHOD, AND COMPOUND FUJIFILM Corporation (JP) 2024-10-02 EP disclosed
CN-118722043-A On-press development type lithographic printing plate precursor, method for producing lithographic printing plate, lithographic printing method, and compound 富士胶片株式会社 2024-10-01 CN disclosed
EP-0652875-A1 (HETERO)-ARYL KETONES DERIVATIVES WITH ANTIBACTERIAL PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1995-05-17 EP disclosed
WO-1994002478-A1 (HETERO)-ARYL KETONES DERIVATIVES WITH ANTIBACTERIAL PROPERTIES SMITHKLINE BEECHAM PLC (GB) 1994-02-03 WO disclosed
EP-0486749-A1 Triarylmethane compounds and pressure sensitive recording material HODOGAYA CHEMICAL CO., LTD. (JP) 1992-05-27 EP disclosed
US-4535052-A HIGH SPEED PHOTORESISTS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-08-13 US disclosed
US-4506089-A TREATMENT OF ISOMER MIXTURE WITH AN EMULSIFIER BASF AKTIENGESELLSCHAFT (DE) 1985-03-19 US disclosed
EP-0127762-A1 Constrained N-alkylamino aryl ketones as sensitizers for photopolymer compositions E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-12-12 EP disclosed
US-4133828-A Manufacture of dimethylaminobenzenesulfonates BASF AKTIENGESELLSCHAFT (DE) 1979-01-09 US disclosed
US-4002664-A Manufacture of dimethylaminobenzenecarboxylic acid esters BASF AKTIENGESELLSCHAFT (DT) 1977-01-11 US disclosed
US-3971821-A Production of aminobenzaldehydes BASF AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12371408-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 KDM4E 2343/4885MAPT 1282/4885ALDH1A1 602/4885
US-20260022099-A1 ARYL HYDROCARBON RECEPTOR AGONISTS AND USES THEREOF AHR, NR1H4, CNR1 KDM4E 2121/4885MAPT 1624/4885ALDH1A1 807/4885
US-20240383868-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 KDM4E 223/4885MAPT 3823/4885ALDH1A1 2230/4885
US-12168646-B2 Aryl hydrocarbon receptor agonists and uses thereof AHR, ARNT, NR1H2 KDM4E 2343/4885MAPT 1282/4885ALDH1A1 602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.