Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TGM2 | P21980 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6417148 | 1.00 | ALDH1A1 (0.51) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4991617 | 0.89 | MAPT (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4991606 | 0.89 | MAPT (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL6843741 | 0.85 | IDO1 (0.55) | TGM2IDO1PDGFRB | |
| SCHEMBL6843739 | 0.85 | IDO1 (0.55) | TGM2IDO1PDGFRB | |
| SCHEMBL4999469 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4999470 | 0.85 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992130 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4992126 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM | |
| SCHEMBL4984870 | 0.82 | MAPT (0.50) | ALDH1A1MAPTNPSR1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050282810-A1 | Oxindole derivatives | HARRIS PHILIP A | 2005-12-22 | — | — | US | claimed |
| US-6964977-B2 | Oxindole derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-15 | — | — | US | claimed |
| US-20030225090-A1 | E.g., 5-(((Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-amino)-1,3-dihydro-2H -benzimidazol-2-one; inhibition or antagonism of protein kinases; treating pain or cancer | SMITHKLINE BEECHAM CORPORATION | 2003-12-04 | — | — | US | claimed |
| US-20050282810-A1 | Oxindole derivatives | HARRIS PHILIP A | 2005-12-22 | — | — | US | disclosed |
| US-6964977-B2 | Oxindole derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-15 | — | — | US | disclosed |
| US-20030225090-A1 | E.g., 5-(((Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-amino)-1,3-dihydro-2H -benzimidazol-2-one; inhibition or antagonism of protein kinases; treating pain or cancer | SMITHKLINE BEECHAM CORPORATION | 2003-12-04 | — | — | US | disclosed |
| EP-1317446-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020513-A1 | OXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282810-A1 | Oxindole derivatives | OPRK1, ERBB2, OGFR | ALDH1A1 3635/4885MAPT 3370/4885NPSR1 1041/4885 |
| US-20030225090-A1 | E.g., 5-(((Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-amino)-1,3-dihydro-2H -benzimidazol-2-one; inhibition or antagonism of protein kinases; treating pain or cancer | ERBB2, DSTYK, OPRK1 | ALDH1A1 3801/4885MAPT 3646/4885NPSR1 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.