Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5973321 | 0.92 | MAPT (0.67) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5972887 | 0.81 | MEN1 (0.60) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5972372 | 0.80 | SMN1; SMN2 (0.62) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7303163 | 0.78 | HDAC3 (0.86) | MAPTMEN1KMT2ASMN1; SMN2HDAC3 | |
| SCHEMBL13483892 | 0.77 | NPC1 (0.71) | MAPTMEN1KMT2AHDAC3HDAC6 | |
| SCHEMBL13483891 | 0.77 | ESR1 (0.76) | MAPTMEN1KMT2ASMN1; SMN2HDAC3 | |
| SCHEMBL22718631 | 0.76 | MAOA (0.56) | TP53MEN1KMT2ASMN1; SMN2HDAC3 | |
| SCHEMBL13293334 | 0.76 | MAPT (0.78) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20773177 | 0.76 | MAPT (0.68) | MAPTTP53MEN1KMT2AKDM4E | |
| SCHEMBL24601353 | 0.76 | MAOA (0.52) | MAPTMEN1KMT2ASMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004133-A1 | Modulators of VR1 receptor | VERTEX PHARMACEUTICALS INCORPORATED | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004133-A1 | Modulators of VR1 receptor | TRPV1, TRPV2, TRPV3 | MAPT 4434/4885TP53 3827/4885MEN1 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.